Posters and Presentations

AACR 2021 Trial in progress abstract: Phase 1 & phase 2a, first-in-human study (FIH) of DRP-104, a broad glutamine antagonist, in adult patients with advanced solid tumors Melissa Johnson, Deborah Doroshow, Tanguy Y. Seiwert, Michael K. Gibson, Vamsidhar Velcheti, Aaron Lisberg, Shetal A. Patel, Matthias Scheffler, Francois Lafleur, Margaret Dugan and Sunil Sharma Download DRP-104, a broad acting glutamine antagonist, synergizes with immune checkpoint blockade in vivo Yumi Yokoyama and Robert Wild Download Broad glutamine pathway inhibition by DRP-104 results in anti-tumor activity in hypermetabolic lung tumors resistant to PD-1 or osimertinib therapy Morgan Brady, Milica Momcilovic, Chiara Montemurro, Yumi Yokoyama, Heather Christofk, Katerina Politi, Margaret Dugan, Aaron Lisberg, Robert Wild and David B. Shackelford Download Halting head and neck squamous cell carcinoma progression by broadly targeting glutamine metabolic pathways Michael Allevato, Sally Trinh,Yumi Yokoyama, Robert Wild and J. Silvio Gutkind Download AACR 2020 Broad acting glutamine antagonism remodels the tumor microenvironment; induces distinctive immune modulation; and synergizes with immune checkpoint blockade Yumi Yokoyama and Robert Wild Download Uncovering metabolic bottlenecks in KEAP1 mutant lung cancer Sarah LeBoeuf, Shih Ming Huang, Christian Bahamon, Triantafyllia Karakousi, Warren Wu, Volkan Sayin, Robert Wild, and Thales Papagiannakopolous Download SITC 2019 DRP-104, a novel broad acting glutamine antagonist, induces distinctive immune modulation mechanisms and synergistic efficacy in combination with immune checkpoint blockade Yumi Yokoyama, Michael Nedelcovych and Robert Wild Download DRP-104, a novel broad acting glutamine antagonist, induces durable anti-tumor responses in vivo by inhibiting tumor glutamine addiction, remodeling the tumor microenvironment and stimulating both the innate and adaptive immune system Yumi Yokoyama, Michael Nedelcovych and Robert Wild Download AACR 2019 Tumor targeted delivery of glutamine antagonist: Use of CES1-/- Mice Rana Rais, Jesse Alt, Ranjeet P. Dash, Alexandra J. Gadiano, Lukáš Tenora, Kateřina Novotná, Pavel Majer, Barbara S. Slusher Download Targeting glutamine metabolism disables warburg physiology by inhibiting proximal glycolysis and krebs cycle rewiring Liang Zhao, Matthew Arwood, Wei Xu, Im-Hong Sun, Im-Meng Sun, MinHee Oh, Chirag Patel, Ryan Jou, Robert Leone, Jesse Alt, Rana Rais, Barbara Slusher, Jonathan D. Powell Download Targeting glutamine metabolism leads to terminal differentiation in acute myeloid leukemia (AML) Robert D. Leone, Im-Meng Sun, Min-Hee Oh, Roshan Chikarmane, Radhika Viswanathan, Sanjeda Patwari, Matthew Arwood, Gabriel Ghiaur, Jonathan Powell Download Targeting glutamine metabolism as a mean of treating a murine model of ovarian cancer and ascites development Min‐Hee Oh, Meghan Travers, Stephen Brown, Liang Zhao, Im‐Meng Sun, Im‐Hong Sun, Matthew Arwood, Wei Xu, Samuel Collins, Robert Leone, Eva Prchalova, Rana Rais, Barbara Slusher, Maureen Horton, Cynthia Zahnow, Jonathan Powell Download JHU395, a nervous tissue penetrant glutamine antagonist, restricts growth of malignant peripheral nerve sheath tumor with inhibition of nucleotide synthesis Kathryn M. Lemberg, Liang Zhao, Ying Wu, Vijayabhaskar Veeravalli, Jesse Alt, Joanna Marie H. Aguilar, Lukáš Tenora, Michael Nedelcovych, Cory Brayton, Pavel Majer, Jaishri Blakeley, Rana Rais, and Barbara S. Slusher Download AACR 2018 Targeting glutamine metabolism as a means of enhancing antitumor T-cell responses Robert Leone, Judson Englert, Im-Meng Sun, Min-Hee Oh, Jesse Alt, Im-Hong Sun, Ada J. Tam, Pavel Majer, Rana Rais, Barbara Slusher and Jonathan Powell Glutamine metabolic inhibition synergizes with L-asparaginase in MYCN-amplified neuroblastoma Micah J. Maxwell, Brad Poore, Allison Hanaford, Jesse Alt, Rana Rais, Barbara S. Slusher, Charles G. Eberhart and Eric H. Raabe Download Targeting glutamine metabolism enhances tumor specific immunity by inhibiting the generation and function of suppressive myeloid cells Min-Hee Oh, Im-Hong Sun, Liang Zhao, Im-Meng Sun, Wei Xu, Chirag Patel, Robert Leone, Ada J. Tam, Judd Englert, Pavel Majer, Rana Rais, Barbara Slusher, Maureen R. Horton and Jonathan D. Powell Download Novel prodrugs of the glutamine antagonist 6-diazo-5-oxo-norleucine (DON) as treatment for malignant peripheral nerve sheath tumor Kathryn Lemberg, Ying Wu, Jesse Alt, Liang Zhao, Alexandra J. Gadiano, Chabely Rodriguez, Rana Rais, Pavel Majer, Jaishri Blakeley and Barbara Slusher Download AACR 2017 Metabolism as checkpoint: Induction of anti-tumor immune response with the novel glutamine antagonist JHU-083 Robert D. Leone, Judson M. Englert, Min-Hee Oh, Chih-Hsien Cheng, Rana Rais, Barbara Slusher, Jonathan D. Powell Download

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